Drag & Drop opening a specific directory on the user's local machine?

I would like to know if it’s possible to use this library/ the File System Access API to open a specific file directory on the user’s machine. I know the file system access API can give the user the ability to browse files to upload on their own, but my intention is to simplify this process by simply guessing the right directory to read from, perhaps by guessing a relative directory?

Thanks in advance